Endocrine Abstracts

Objective: There is a complex cross-talk between bone and glucose metabolism. The surrogate markers of bone metabolism are osteocalcin (for bone formation) and CTx (for bone resorption). The osteoblast-derived protein osteocalcin has recently been shown to affect glucose homeostasis.Aim of the study: To investigate the relationship between markers of bone metabolism and parameters reflecting bone composition, glucose homeostasis and insulin resistance in...

Posttreatment assessment of the disease activity and definition of cure of acromegaly, by measuring GH secretion, remains problematic. Furthermore, with our efforts to achieve tight biochemical control of the disease it is foreseeable that a proportion of patients may be rendered GH deficient (GHD). The aim of our study was to evaluate residual GH secretion in cured patients with acromegaly. The study was approved by the Hospital Ethical Committee and after informed consent, b...